李小明

人物 | 行業人物 | 醫生 | 同濟醫院放射科副主任

李小明,女,醫學博士。現為 同濟醫院 放射科副主任,肌肉骨關節影像診斷學術帶頭人。教授、主任醫師、博士生導師。“華中學者”特聘教授。

擅長領域

在全國率先開展了各類關節炎影像診斷的臨床新技術新業務工作,取得的成績位于國際前列,已為大量患者解決了眾多疑難問題。主要擅長于:各種慢性關節炎( 類風濕性關節炎強直性脊柱炎 、退行性骨關節炎、 痛風性關節炎 、其它各種關節炎等),因代謝、血液系統疾病引起的骨關節病變,骨缺血性壞死,肌骨關節外傷, 骨腫瘤軟組織腫瘤 ,骨關節感染性病變,骨軟骨發育異常等的影像學診斷。

學術兼職

全球綜合性影像診斷雜志影響因子排名第二《Investigative Radiology》(在美國出版)在中國的唯一編委。國家自然科學基金二審專家。中華放射學會骨關節專業委員會副主任委員。《European Radiology》、《Journal of Magnetic Resonance Imaging》、《Journal of Neurology》等雜志的審稿專家。

研究項目

(一) 3項在研國家自然科學基金項目:

1. 國家自然科學基金重點項目“椎間盤細胞及分子生物力學應答機制的影像學研究”(項目批準號: 31630025, 經費:307萬,時間:2017.1至2021.12);

2. 國家自然科學基金重大國際合作項目“SpA/AS的免疫學發病機制和早期病理改變特征的影像學研究”(項目批準號:81320108013, 經費:280萬元, 時間:2014.1至2018.12);

3. 國家自然科學基金面上項目“早期類風濕性關節炎的滑膜炎發病機制的影像學研究” (項目批準號:81571643,經費:78萬,時間:2016.1至2019.12)。

(二)5項已結題國家自然科學基金項目:

1. 國家自然科學基金面上項目“小兒股骨頭骨 骺 缺血的早期磁共振診斷方法” (項目批準號:30370430,經費:18萬元,時間:2004.01至2006.12);

2. 國家自然科學基金面上項目“MR 彈性成像 檢測損傷性關節軟骨力學性質變化的研究”(項目批準號:30670605,經費: 30萬元,時間:2007.01至2009.12);

3.國家自然科學基金面上項目“ 生長板 內個體 軟骨細胞 的分子顯微 磁共振成像 研究”(項目批準號:30870701,經費: 35萬元,時間:2009.01至2011.12);

4.國家自然科學基金面上項目“軟骨終板早期退變的μMRI研究” (項目批準號:81071133,經費:34萬元,時間:2011.01至2013.12)

5. 國家自然科學基金面上項目“骺板軟骨細胞力學應答的顯微磁共振成像研究” (項目批準號:31170899,經費: 60萬元,時間:2012.01至2015.12)。

(三) 1項在研同濟醫院 轉化醫學 項目:

同濟醫院十大轉化醫學研究項目“早期椎間盤退行性變的磁共振成像研究”(項目批準號:2016ZHYXXM007,經費:50萬,時間:2017.1至2018.12)

獲獎情況

曾獲湖北省科技進步三等獎及全軍科技進步三等獎。

主要論文

以第一作者或通訊作者發表了SCI期刊論文30余篇。

(1) Wu Gang, Yang Jun, Zhang Tianjing, Morelli John N, Giri Shivram, Li Xiaoming*, Tang Wenlin. The diagnostic value of non-contrast enhanced quiescent interval single shot (QISS) magnetic resonance angiography at 3T for lower extremit rial disease, in comparison to CT angiography. Journal of Cardiovascular Magnetic Resonance, 2016 Oct 20; 18(1):71. DOI 10.1186/s12968-016-0294-6

(2) Wu Gang, Jin Teng, Li Ting, Morelli John, Li Xiaoming*. High spatial resolution time-resolved magnetic resonance angiography of lower extremity tumors at 3T: Comparison with computed tomography angiography. Medicine. 2016 Sep; 95(37): e4894

(3) Ran J, Liu Y, Sun D, Morelli J, Zhang P, Wu G, Sheng Y, Xie R, Zhang X, Li X*. The diagnostic value of biexponential apparent diffusion coefficients in myopathy. J Neurol. 2016 Jul; 263(7):1296-302.

(4) Zhang Ping, Yu Kaihu, Guo Ruimin, Ran Jun,Liu Yao,Morelli John, Runge A Val, Li Xiaoming*. Comparing the diagnostic utility of sacroiliac spectral CT and MRI in axial spondyloarthritis. Br J Radiol. 2016; 89(1059): 20150196

(5) Zhang P, Yu KH, Guo RM, Ran J, Liu Y, Morelli J, Runge VM, Li XM*. A novel diagnostic method (spectral computed tomography of sacroiliac joints) for axial spondyloarthritis. J Formos Med Assoc. 2016 Aug; 115(8):658-64.

(6) Shen Y, Goerner F, Runge VA, Hao D, Hu D, Li X*. T1 relaxivities of Gadolinium-Based Magnetic Resonance Contrast Agents in Human Whole Blood at 1.5, 3 and 7 Tesla. Investigative Radiology. 2015 May; 50(5):330-338.

(7) Zhu T, Ai T, Zhang W, Li T, Li X*. Segmental Quantitative MR Imaging Analysis of Diurnal Variation of Water Content in the Lumbar Intervertebral Discs. Korean J Radiol. 2015; 16(1):139-145.

(8) Zhang P, Yu K, Guo R, Shah S, Morelli JN, Runge VA, Li X*. Ankylosing spondylitis: correlations between clinical and MRI indices of sacroiliitis activity. Clin Radiol. 2015 Jan; 70(1):62-6.

(9) Ai T, Yu K, Gao L,Zhang P, Goerner F, Runge VM, Li X*. Diffusion Tensor Imaging in Evaluation of Thigh Muscles in Patients with Polymyositis and Dermatomyositis. Br J Radiol. 2014 Nov;87(1043):20140261.

(10) Ai T, Goerner F, Patel N, Trelles M, Wu G, Li X*, Runge VM. Contrast Dose, Temporal Footprint, and Spatial Resolution Tradeoffs in Dynamic Contrast-Enhanced MRA Performed in a Porcine Model of a Carotid Aneurysm. Journal of computer assisted tomography. Jan 2013;37(1):105-110

(11) PAN Chu, HU Dao-yu, ZHANG Wei, LI Xiao-ming*. Role of diffusion-weighted imaging in early ankylosing spondylitis. Chin Med J 2013;126 (4):668-673.

(12) Morelli JN, Runge VM, Ai F, Zhang W, Li X*, Schmitt P, McNeal G, Michaely H, Schoenberg SO, Miller M, Gerdes CM, Sincleair ST, Spratt H, Attenberger UI. MR Evaluation of Renal Artery Stenosis in a Swine Model: Performance of Low-Dose Gadobutrol versus Gadoterate Meglumine with Comparison to DSA. Investigative Radiology. 2012; 47(6). 2012; 47(6):376-382.

(13) Tao Ai, Abraham P, Frank G, Mathias N, Zbigniew G, Siddharth J,Miguel T,Raleigh FJ, Ronald W, Xiaoming Li * ,Val M R . SEMAC-VAT and MSVAT-SPACE Sequence Strategies for Metal Artifact Reduction in 1.5T Magnetic Resonance Imaging. Investigative Radiology. 2012; 47(5): 267-276.

(14) Morelli JN, Ai F, Runge VM, Zhang W, Li X*, et al. Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation. J Magn Reson Imaging. 2012; 36(3):704-13.

(15) Fei Ai, Tao Ai, Xiaoming Li*, Daoyu Hu, Wei Zhang, John N. Morelli. Value of diffusion-weighted magnetic resonance imaging in early diagnosis of ankylosing spondylitis. Rheumatology nternational. 2012; 32(12):4005-13 .

(16) Ai Tao,Zhang Wei,Priddy N.K.,Xiaoming Li*. Diagnostic performance of CUBE MRI sequences of the knee compared with conventional MRI. Clinical Radiology. 2012; 67 :e58-e63.

(17) Ai Fei, YuCheng, ZhangWei, Morelli John, Kacher Daniel, Li Xiaoming*. MR Imaging of The Knee Osteoarthritis With Pain. J Huazhong Univ Sci. 2010; 30(2): 248-254.

(18) Li X, Yu C, Wu H, Daniel K, Hu D, Xia L, Pan C, Xu A, Hu J, Wang L, Peng W, Li F. Prospective comparison of 3D FIESTA versus fat-suppressed 3D SPGR MRI in evaluating knee cartilage lesions. Clin Radiol. 2009; 64 (10):1000-1008.

(19) Li X, Peng WJ, Wu H, Kacher D, Xia LM, Ai F, Li F, Xiong W. MRI findings of injured articular cartilage of the knee with surgical correlation. Chin Med J (Engl). 2009 Nov 5; 122(21):2624-2630.

(20) Li X, Qi J, Xia L, Li H, Hu J, Yu C, Pen W, Guan J, Hu D. Diffusion MRI in Ischemic Epiphysis of the Femoral Head:An Experimental Study. J Magn Reson Imaging. 2008 Aug; 28(2):471–477.

(21) Li X, Qi J, Xia L, Yu C, Peng W, Hu X, Hu D, Feng D, Hu J, Qiu L, Li H. Dynamic gadolinium-enhanced MRI in early ischaemia of the proximal femoral epiphysis--a preliminary study. Clin Radiol. 2008 Oct; 63(10):1149-1159.

(22) Li X, Xiong W, Hu DY, Yu C, Peng WJ, Hu JW, Feng DY, Hu XM, Li HL, Qiu L, Li F. Dynamic gadoteridol-enhanced MR imaging in the end of growing long bone of piglets. Chin Med J (Engl). 2008 Oct 5; 121(19):1932-1938.

(23) Menezes NM., Li X*, Olear EA, Connolly SA, Zurakowski D, Foley M, Shapiro F, Jaramillo D. Gadolinium-Enhanced Images of the Growing Piglet Skeleton: Ionic versus Nonionic Contrast Agent. Radiology. 2006 May; 239(2): 406-414.

(24) Li X, Hu J, Zhen H, Tang L, Xu A. Early reversible ischemia of femoral head epiphysis in piglets on gadolinium -enhanced MRI: an experimental study. J Huazhong Univ Sci Technolog Med Sci. 2006;26(4):482-484.

(25) Li X, Wang R, Qi J, Tang L. Gadolinium-enhanced MR imaging of epiphyseal and metaphyseal marrow in normal piglets. J Huazhong Univ Sci Technolog Med Sci. 2005;25(4):461-463

(26) Li X,Wang R, Li Y, Tang L, Hu J, Xu A. Gadolinium-enhanced MR imaging in developing epiphysis of normal piglets : an experimental study. J Huazhong Univ Sci Technolog Med Sci.2005;25(2):209-211

(27) LI Xiaoming, WANG Ren-fa, LI Yong-gang, TANG Li-hua, YANG Bo. Growth Cartilage of Piglet: Correlation between MRI Characteristics and Histologic Findings and Measurements of T1 and T2 Relaxation Time. Journal of Nanjing Nedical University. 2004; 18(5) :244-249.

(28) Li X,Wang R, Li Y, Tang L, Xu A, Hu J. MRI characteristics and transverse relaxation time measurements in normal growing cartilage. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):411-413

(29) Xiaoming Li , Xavier Leclerc , Thierry Huisman, A. Gregory Sorensen.DT- MRI of Central Nervous System : Clinical Applications. CNS SPECTRUMS. July 2002;7 (7):535-541.

(30) Xiaoming Li, Chengyuan Wang,et al. MR Imaging of the Pancreas. Journal of Xi’an Medical University. 2000; Vol.12 No.1 40-45.

中文名
李小明
性別
民族
漢族
職業
武漢同濟醫院放射科主任醫師
臨床職稱
教學職稱
執業地點